The Murciélago sports a 6.2-litre version of the Lamborghini V12 engine, a six-speed manual or six-speed sequential automatic transmission, and four-wheel drive. It also has a rear spoiler that can be raised to an angle of 70 degrees, side mirrors that fold in to improve aerodynamics, and side scoops that automatically open to the needed size to let in just the right amount of air needed to cool its engine. The 2008 car's fuel economy is 8miles per US gallon (29L/100km; 9.6mpg-imp) city and 13miles per US gallon (18L/100km; 16mpg-imp) freeway, making it the least efficient 2008 car for city and highway driving, according to the EPA.
The coupé's base price is US $313,000, which is US $107,000 more than its smaller sibling, the Lamborghini Gallardo.
In 2006 the Murciélago's engine was replaced by a stronger 6.5-liter engine and the car's name was changed to Murciélago LP640. For the 2007 model year Lamborghini did the same with the roadster model, which is now called Murciélago LP640 Roadster. Both versions received a minor facelift.